Too much iron, may negatively impact fertility. Thus, under high body iron conditions, serum hepcidin levels rise and ferroportin expression decreases. J Neurol — [ Abstract ] [ Google Scholar ]. Recent history Saved searches. Andrologia 49 :e [ Abstract ] [ Google Scholar ].
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It may be difficult to determine whether altered semen parameters are directly due to iron overload, reactive oxygen species, hypogonadism, or a combination of these factors. March 4th, 0 Comments. A histologic, immunocytologic, and ultrastructural study.
Impaired mitochondrial function would be expected to be harmful given the extensive mitochondrial biogenesis that occurs during spermatogenesis. Nonetheless, it appears that severe iron overload may also negatively impact ejaculatory function. The literature regarding seminal plasma iron concentrations in men with abnormal semen analyses is inconsistent for the general population [ 31 — 33 ].
The human body lacks a mechanism for eliminating excess iron [ 2 ]. Interestingly, iron regulation within the Sertoli cell is particularly complex as there is a polarized gradient of iron concentrations that decreases toward the lumen of the seminiferous tubules.
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